Lysine-specific histone demethylases in normal and malignant hematopoiesis
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چکیده
منابع مشابه
Histone lysine demethylases in Drosophila melanogaster
Epigenetic regulation of chromatin structure is a fundamental process for eukaryotes. Regulators include DNA methylation, microRNAs and chromatin modifications. Within the chromatin modifiers, one class of enzymes that can functionally bind and modify chromatin, through the removal of methyl marks, is the histone lysine demethylases. Here, we summarize the current findings of the 13 known histo...
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Methylation marks on the lysine residues of histone proteins are thought to contribute to epigenetic phenomena in part because of their apparent irreversibility. Will this view change with the recent discovery of histone lysine demethylases that reversibly remove methyl marks?
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ژورنال
عنوان ژورنال: Experimental Hematology
سال: 2016
ISSN: 0301-472X
DOI: 10.1016/j.exphem.2016.05.006